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Excellence Award of “National R&D Real Challenge” to Department of Biochemistry of Graduate School N

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  • Date : 2022.01.12 10:49
  • Publication Date : 2022.01.06
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Development of highly sensitive quick autoimmunity diagnosis kit for COVID-19 with antibody immobilization

Study on “improvement of sensitivity of quick autoimmunity diagnosis kit” led by Professor KIM Chang-seop of Department of Chemistry and Biochemistry, etc.

[January 6, 2022]


<Research team of Department of Biochemistry of YU Graduate School> (From the left, Professor KIM Chang-seop and investigators KIM Kyeong-rok and LEE Ae-seol)

  YU research team proposed a method for quick diagnosis of COVID-19 and received attention.

Excellence award of “National R&D Real Challenge” was given to the task of “highly sensitive quick autoimmunity diagnosis kit for COVID-19 with antibody immobilization” proposed by KIM Kyeong-rok (doctorate completion), LEE Ae-seol (doctorate 2nd year), and KIM Su-min (2nd year of master). The task was led by Professor KIM Chang-seop of Department of Biochemistry of YU and Chief Investigator SHIN Hwa-hee of Diagnostic Medical Device Team of Daegu Gyeongbuk Medical Innovation Foundation.

YU research team proposed a method to improve low sensitivity of COVID-19 autoimmunity diagnosis kits which has been pointed out as an issue. They proposed “Quick autoimmunity diagnosis kit based on fusion protein and cellulose.”

https://www.yu.ac.kr/_attach/yu/editor-image/2022/01/KcPjyvGBuixhOfbWuMJNNCuLkW.jpg  Investigator KIM Kyeong-rok explained the performance of the study saying, “Commercialized quick autoimmunity diagnosis kits have the advantages of low prices and availability for nonprofessionals but, as antibodies are immobilized on nitrocellulose membranes, the sensitivity is significantly low. In addition, if samples are not collected by accurate ways, the sensitivity decreases. Therefore, we intended to improve the sensitivity of the quick autoimmunity diagnosis kit for detection of COVID-19 by immobilizing antigen-binder of antibody so that is exposed out of cellulose membranes with use of the antibody immobilization method developed by our laboratory. Also, accurate sampling is possible because color change may be identified with use of pH-sensitive sampling cotton swab.”

“NationalR&D Real Challenge Program” supported by the Ministry of Information & Communication and managed by Korea Institute of Human Resources Development in Science and Technology (KIRD)” is a program to strengthen research capability of engineering doctorate/master graduate school students. Graduate school students select “free subjects on solution of social and human pending issues and development of new technologies,” establish research plans, and perform duties.